Development of continuous non-invasive monitoring for early detection and prevention of serious morbidity and mortality after abdominal cancer-surgery

Major elective cancer surgery in the abdomen is associated with substantial morbidity and mortality risk despite optimized anesthesia and surgical techniques.Thus, it is estimated that severe morbidity occurs in 25-35% after abdominal cancer surgery within the first 30 days.

Postoperative acute mortality is similarly unacceptably high, evidenced by national data showing 8-9% in-hospital mortality after upper abdominal surgery, and also significant 90-day mortality. The high morbidity and mortality rates after abdominal cancer surgery are in discrepancy with the fact that these procedures are performed with a curative or life prolonging aim.

Using spectral analysis of a wide range of continuously measured physiological parameters, we will seek to develop an algorithm for prediction of severe postoperative complications after abdominal cancer surgery and define a set of criteria for intervention against severe postoperative events.

Hence, the aim is to achieve continuous patient surveillance with a ’wear and forget’ device, for early intervention to prevent the development of a number of postoperative complications, with reduced morbidity, mortality and health care costs, increasing overall survival after cancer treatment.

This project is co-funded by the Knæk Cancer Foundation.